RESEARCH

Research Interests

My PhD advisor is Dr. Mette Olufsen, and I am a member of the Cardiovascular Dynamics Group at NCSU. My research focuses on applying mathematical concepts to problems in cardiovascular health. My general research interests include mathematical modeling, cardiovascular physiology, and computational fluid dynamics.

Pulmonary hypertension due to left heart failure

We use in-silico computational fluid dynamics of large and small pulmonary arteries and veins to predict wall shear stress (WSS) and cyclic stretch (CS), quantities serving as biomarkers for disease severity of pulmonary hypertension due to left heart failure. We calculate dynamic blood pressure, blood flow, area deformation, WSS, and CS in the pulmonary circulation, providing a new way to investigate hypotheses related to disease progression.

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Development of a pulmonary arteriolar-alveolar capillary model

The pulmonary capillaries surround the alveoli and have an irregular branching pattern that is distinct from the tubular structure of arteries and veins. The dense capillary network can be most accurately modeled by a sheet of fluid flowing between two membranes. We develop a model for the capillaries that connects each arteriole segment to the corresponding venule segment in a ladderlike manner. This allows us to create a multiscale model that contains large arteries and veins, arterioles and venules, and capillaries, enabling dynamics predictions of pressure and flow in the complete pulmonary circulation.

Publications

Computational framework for the generation of one-dimensional vascular models accounting for uncertainty in networks extracted from medical images
MA Bartolo, AM Taylor-LaPole, D Gandhi, A Johnson, Y Li, E Slack, I Stevens, Z Turner, J Weigand, C Puelz, D Husmeier, MS Olufsen
December 2023

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Numerical predictions of shear stress and cyclic stretch in pulmonary hypertension due to left heart failure
MA Bartolo, MU Qureshi, MJ Colebank, NC Chesler, MS Olufsen
Biomechanics and Modeling in Mechanobiology
January 2022

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Multiscale analysis of remodeling in pulmonary hypertension due to left heart failure
MA Bartolo, MA Haider, NA Hill, MS Olufsen
Proceedings of the 7th International Conference on Computational & Mathematical Biomedical Engineering
June 2022

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Multiscale computational model predictions of shear stress and cyclic stretch in the pulmonary circulation
MA Bartolo, NA Hill, NC Chesler, MS Olufsen
Proceedings of Summer Biomechanics, Bioengineering, and Biotransport Conference
June 2021

Presentations

Cardiac Physiome Workshop: Poster Session
April 2023
One-dimensional multiscale modeling of the pulmonary microcirculation

NC State Mathematics Graduate Student Recruitment Weekend
February 2023
Pulmonary hypertension assessed using a fluid mechanics model

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NC State Biomathematics Seminar
September 2022
Development of a multiscale computational model of the pulmonary micro-circulation to study pulmonary hypertension

9th World Congress of Biomechanics: Poster Session
July 2022
A one-dimensional computational model of the pulmonary circulation using structured trees coupled with a sheet model for alveolar flow

7th International Conference on Computational and Mathematical Biomedical Engineering
June 2022
Multiscale analysis of remodeling in pulmonary hypertension due to left heart failure

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University of California, Irvine: Chesler Group Meeting
August 2021
Multiscale computational model predictions in the pulmonary vasculature during pulmonary hypertension

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SIAM Annual Meeting: AWM Poster Session
July 2021
Numerical predictions of shear stress and cyclic stretch in the pulmonary vasculature

5th St. Andrews SofTMech Soft Tissue Modelling Workshop
June 2021
Multiscale hemodynamic predictions in the pulmonary vasculature

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SIAM Conference on Computational Science and Engineering
March 2021
Numerical predictions of shear stress and cyclic stretch in the healthy pulmonary vasculature

Marist College Mathematics Seminar
May 2019
Passive acoustic monitoring of marine mammals in the Indian Ocean

Summer Biomechanics, Bioengineering, and Biotransport Conference
June 2021
Multiscale computational model predictions of shear stress and cyclic stretch in the pulmonary circulation

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46th Annual New York State Regional Graduate Mathematics Conference
April 2021
Multiscale model predictions of mechanical forces in the pulmonary vasculature

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178th Meeting of the Acoustical Society of America
December 2019
Analysis and automatic detection of potential Omura's whale signals in the Indian Ocean

Marist College Celebration of Undergraduate Research, Scholarship, and Creative Activity
April 2019
Passive acoustic monitoring of marine mammals in the Indian Ocean

RESEARCH

Research Interests

Publications

Computational framework for the generation of one-dimensional vascular models accounting for uncertainty in networks extracted from medical images MA Bartolo, AM Taylor-LaPole, D Gandhi, A Johnson, Y Li, E Slack, I Stevens, Z Turner, J Weigand, C Puelz, D Husmeier, MS Olufsen December 2023

Numerical predictions of shear stress and cyclic stretch in pulmonary hypertension due to left heart failure MA Bartolo, MU Qureshi, MJ Colebank, NC Chesler, MS Olufsen Biomechanics and Modeling in Mechanobiology January 2022

Multiscale analysis of remodeling in pulmonary hypertension due to left heart failure MA Bartolo, MA Haider, NA Hill, MS Olufsen Proceedings of the 7th International Conference on Computational & Mathematical Biomedical Engineering June 2022

Multiscale computational model predictions of shear stress and cyclic stretch in the pulmonary circulation MA Bartolo, NA Hill, NC Chesler, MS Olufsen Proceedings of Summer Biomechanics, Bioengineering, and Biotransport Conference June 2021

Presentations

Cardiac Physiome Workshop: Poster Session April 2023 One-dimensional multiscale modeling of the pulmonary microcirculation

NC State Mathematics Graduate Student Recruitment Weekend February 2023 Pulmonary hypertension assessed using a fluid mechanics model

NC State Biomathematics Seminar September 2022 Development of a multiscale computational model of the pulmonary micro-circulation to study pulmonary hypertension

9th World Congress of Biomechanics: Poster Session July 2022 A one-dimensional computational model of the pulmonary circulation using structured trees coupled with a sheet model for alveolar flow

7th International Conference on Computational and Mathematical Biomedical Engineering June 2022 Multiscale analysis of remodeling in pulmonary hypertension due to left heart failure

University of California, Irvine: Chesler Group Meeting August 2021 Multiscale computational model predictions in the pulmonary vasculature during pulmonary hypertension

SIAM Annual Meeting: AWM Poster Session July 2021 Numerical predictions of shear stress and cyclic stretch in the pulmonary vasculature

5th St. Andrews SofTMech Soft Tissue Modelling Workshop June 2021 Multiscale hemodynamic predictions in the pulmonary vasculature

SIAM Conference on Computational Science and Engineering March 2021 Numerical predictions of shear stress and cyclic stretch in the healthy pulmonary vasculature

Marist College Mathematics Seminar May 2019 Passive acoustic monitoring of marine mammals in the Indian Ocean

Summer Biomechanics, Bioengineering, and Biotransport Conference June 2021 Multiscale computational model predictions of shear stress and cyclic stretch in the pulmonary circulation

46th Annual New York State Regional Graduate Mathematics Conference April 2021 Multiscale model predictions of mechanical forces in the pulmonary vasculature

178th Meeting of the Acoustical Society of America December 2019 Analysis and automatic detection of potential Omura's whale signals in the Indian Ocean

Marist College Celebration of Undergraduate Research, Scholarship, and Creative Activity April 2019 Passive acoustic monitoring of marine mammals in the Indian Ocean

Marist College Honors program Thesis Exhibit: Poster Session December 2018 Passive acoustic monitoring of marine mammals in the Indian Ocean